List of biotoxin products

About the list

• Products are organized by category.
• Availability status of the products is with the description.
• Prices are in Canadian dollars and subject to change without notice.

Certified reference materials produced by NRC

Amnesic Shellfish Poisoning (ASP) Toxins	Description	Unit Table 1 note 1	Price in CAD
CRM-ASP-Mus-d	CRM-ASP-Mus-d is a thermally sterilized homogenate of mussel tissue (Mytilus edulis) contaminated with domoic acid (DA) and some of its isomers. Each unit contains two ~4 g of the homogenate. The DA concentration is 49 µg/g. Used in conjunction with CRM-DA-f, this CRM will assure the reliability of your domoic acid analyses. Status: Available	(2) 4 g bottles	$160
CRM-DA-f	CRM-DA-f is a certified calibration solution for domoic acid (DA), the toxin responsible for Amnesic Shellfish Poisoning (ASP). Each ampoule contains ~0.5 mL of solution with 327 µM DA in acetonitrile/water (1:19, v/v) at a concentration suitable for calibration of liquid chromatography experiments and for spiking shellfish control samples for recovery experiments. Status: Available	0.5 mL/ampoule	$80
RM-ASP-Mus (non-certified)	With the launch of CRM-ASP-Mus-b, the remaining stock of RM-ASP-Mus (formerly known as MUS-1) has been withdrawn from the certified list. RM-ASP-Mus is, however, still available as a research material. Each bottle contains 15 g of tissue with a domoic acid concentration of 98 µg/g. Status: Available	15 g/bottle	$130

Diarrhetic Shellfish Poisoning (DSP) and other Lipophilic Toxins	Description	Unit Table 2 note 1	Price in CAD
CRM-AZA1	CRM-AZA1 is a certified calibration solution for the determination of azaspiracid-1 (AZA1) by chemical analysis methods. Each ampoule contains ~0.5 mL of solution with 1.47 μM AZA1 in methanol. Status: Available	0.5 mL/ampoule	$130
CRM-AZA2	CRM-AZA2 is a certified calibration solution for the determination of azaspiracid-2 (AZA2) by chemical analysis methods. Each ampoule contains ~0.5 mL of solution with 1.5 μM AZA2 in methanol. Status: Available	0.5 mL/ampoule	$206
CRM-AZA3	CRM-AZA3 is a certified calibration solution for the determination of azaspiracid-3 (AZA3) by chemical analysis methods. Each ampoule contains ~0.5 mL of solution with 1.25 μM AZA3 in methanol. Status: Available	0.5 mL/ampoule	$206
CRM-AZA-Mus	CRM-AZA-Mus is a certified reference material (CRM) prepared from naturally contaminated mussel tissues (Mytilus edulis) containing azaspiracids. CRM-AZA-Mus is designed to assist the analyst in assessing entire analytical methods used to monitor AZA toxins in shellfish tissues. Each bottle contains ~8 g of mussel homogenate with AZAs at levels appropriate for analytical testing. The certified values for CRM-AZA-Mus are: AZA1 - 1.16 μg/g, AZA2 - 0.273 μg/g and AZA3 - 0.211 μg/g. Status: Available	8 g/bottle	$175
CRM-DSP-Mus-b	CRM-DSP-Mus-b is a homogenized blend of blue mussel (Mytilus edulis) digestive gland tissue and a small amount of the dinoflagellate Prorocentrum lima. CRM-DSP-Mus-b is distributed in polypropylene bottles, each containing ~3.9 g of homogenate. The toxin level for okadaic acid is 10.1 µg/g. The toxin level for DTX1 is 1.3 µg/g. These concentrations are suitable for determination by LC-MS or by LC-FLD after ADAM derivitization. Status: Available	4 g/bottle	$160
CRM-DTX1	CRM-DTX1 is a certified calibration solution for the determination of dinophysistoxin-1 (DTX-1) by chemical analysis methods. Each ampoule contains ~0.5 mL of a solution DTX1 in methanol at a concentration of 18.5 µM. Status: Available	0.5 mL/ampoule	$162
CRM-DTX2	CRM-DTX2 is a certified calibration solution for the determination of dinophysistoxin-2 (DTX-2) by chemical analysis methods. Each ampoule contains ~0.5 mL of a solution DTX2 in methanol at a concentration of 9.7 µM. Status: Available	0.5 mL/ampoule	$194
CRM-GYM	CRM-GYM is a certified calibration solution for the determination of gymnodimine (GYM) by chemical analysis methods. Each ampoule contains ~0.5 mL of a solution of GYM in methanol at a concentration of 9.9 µM. GYM is a member of the spiroimine group of toxins. Status: Available	0.5 mL/ampoule	$110
CRM-hYTX	CRM-hYTX is a certified calibration solution for the determination of homo-yessotoxin (hYTX) by chemical analysis methods. Each ampoule contains ~0.5 mL of solution of hYTX in methanol at a concentration of 5.0 μM. Status: Available	0.5 mL/ampoule	$110
CRM-OA-c	CRM-OA-c is a certified calibration solution for the determination of okadaic acid (OA) by chemical analysis methods. Each ampoule contains ~0.5 mL of a solution of OA in methanol at a concentration of 17 µM. Okadaic acid (OA) is one of the principal toxins associated with Diarrhetic Shellfish Poisoning (DSP). Status: Available	0.5 mL/ampoule	$130
CRM-PTX2	CRM-PTX2 is a certified calibration solution for the determination of pectenotoxin-2 (PTX2) by chemical analysis methods. Each ampoule contains ~0.5 mL of a solution of PTX2 in methanol at a concentration of 10.0 µM. PTX2 is a member of the pectenotoxin group of polyether toxins. Status: Temporarily unavailable	0.5 mL/ampoule	$130
CRM-SPX1	CRM-SPX1 is a certified calibration solution for the determination of spirolides by chemical analysis methods. Each ampoule contains ~0.5 mL of a solution of 13-desmethyl spirolide C in methanol at a concentration of 10.2 µM. Spirolides are members of the spiroimine group of toxins, which includes gymnodimine, pinnatoxins and pteriatoxins. Spiroimine toxins cause a characteristic rapid death in the mouse bioassay and have been called "fast-acting toxins". Status: Available	0.5 mL/ampoule	$130
CRM-YTX-b	CRM-YTX-b is a certified calibration solution for the determination of yessotoxin (YTX) by chemical analysis methods. Each ampoule contains ~0.5 mL of solution YTX at a concentration of 4.9 μM in methanol. Status: Available as of July 3, 2012	0.5 mL/ampoule	$120

Paralytic Shellfish Poisoning (PSP)	Description	Unit Table 3 note 1	Price in CAD
CRM-C1&2-b	CRM-C1&2-b is a certified calibration solution designed for use in chemical analysis methods. Each ampoule contains ~0.5 mL solution of C1&2 dissolved in filtered, aqueous acetic acid (~17 μM, pH 5). Concentration is 113.4 µM for C1 and 33.9 µM for C2. Status: Available	0.5 mL/ampoule	$160
CRM-dcGTX2&3-b	CRM-dcGTX2&3-b is a certified calibration solution designed for use in chemical analysis methods. Each ampoule contains ~0.5 mL solution of a mixture of decarbamoylgonyautoxin-2 at a concentration of 116 µM and decarbamoylgonyautoxin-3 at a concentration of 26.1 µM in filtered, aqueous 0.003 M hydrochloric acid plus 0.01 M acetic acid. Status: Available	0.5 mL/ampoule	$160
CRM-dcNEO-c	CRM-dcNEO-c is a certified calibration solution designed for use in chemical analysis methods. Each ampoule contains ~0.5 mL of a solution of decarbamoyl-neosaxitoxin (dcNEO) dissolved in filtered, aqueous 3 mM hydrochloric acid at a concentration of 29.4 µM. Status: Available	0.5 mL/ampoule	$160
CRM-dcSTX-b	CRM-dcSTX-b is a calibration solution CRM designed for use in chemical analysis methods. Each ampoule contains 0.5 mL solution of decarbamoylsaxitoxin at a concentration of 65 µM in 0.003 M hydrochloric acid. Status: Available	0.5 mL/ampoule	$160
CRM-GTX1&4-c	CRM-GTX1&4-c is a certified calibration solution designed for use in chemical analysis methods. Each ampoule contains ~0.5 mL solution of a mixture of gonyautoxin-1 (GTX1) at a concentration of 60.4 µM and gonyautoxin-4 (GTX4) at a concentration of 19.7 µM in 0.003 M hydrochloric acid plus 0.01 M acetic acid. Status: Available	0.5 mL/ampoule	$160
CRM-GTX2&3-c	CRM-GTX2&3-c is a certified calibration solution designed for use in chemical analysis methods. Each ampoule contains ~0.5 mL solution of a mixture of gonyautoxin-2 (GTX2) at a concentration of 114.2 µM and gonyautoxin-3 (GTX3) at a concentration of 43.4 µM in 0.003 M hydrochloric acid plus 0.01 M acetic acid. Status: Available	0.5 mL/ampoule	$160
CRM-GTX5-b	CRM-GTX5-b is a certified calibration solution designed for use in chemical analysis methods. Each ampoule contains ~0.5 mL solution of gonyautoxin-5 (GTX5, aka B1) at a concentration of 65 µM in filtered, aqueous acetic acid (17 µM, pH 5). Status: Temporarily unavailable	0.5 mL/ampoule	$160
CRM-NEO-c	CRM-NEO-c is a certified calibration solution designed for use in chemical analysis methods. Each ampoule contains ~0.5 mL solution of neosaxitoxin (NEO) at a concentration of 65.6 µM in 0.003 M hydrochloric acid. Status: Available	0.5 mL/ampoule	$160
CRM-STX-f	CRM-STX-f is a certified calibration solution for use in chemical analysis methods. Each ampoule contains ~0.5 mL of a solution of saxitoxin (STX) dissolved in filtered, aqueous 3 mM hydrochloric acid at a concentration of 66.3 µM. Status: Available	0.5 mL/ampoule	$160

Negative control CRMs

Identifier	Description	Unit Table 4 note 1	Price in CAD
CRM-Zero-Mus	CRM-Zero-Mus is a mussel tissue (Mytilus edulis) matrix CRM intended for use as a negative control for the analysis of paralytic shellfish toxins (PST), domoic acid (DA) and its isomers, okadaic acid (OA) and diniphysistoxins (DTX), azaspiracids (AZA), yessotoxins (YTX), pentenotoxins (PTX) and gymnodimine (GYM). CRM-Zero-Mus is not suitable as a negative control for spirolides (SPX) and pinnatoxins (PnTX) because these toxins are present, albeit at very low levels. Status: Available	8 g/bottle	$67

Cyanobacterial Toxins	Description	Unit Table 5 note 1	Price in CAD
CRM-ATX	CRM-ATX is a certified calibration solution for the determination of anatoxin-a (ATX) by chemical analysis methods. Each ampoule contains ~0.5 mL of solution with 30 μM ATX dissolved in methanol/water (9:91, v/v) with 0.1% acetic acid. Status: Available	0.5 mL/ampoule	$112
CRM-CYN	CRM-CYN is a certified calibration solution for the determination of cylindrospermopsin (CYN) by chemical analysis methods. Each ampoule contains ~0.5 mL of solution with 30 μM of cylindrospermopsin in filtered, deionized water. Status: Available	0.5 mL/ampoule	$110