NRC DPR 2011-12 – Supplementary information

Departmental Performance Report (DPR) 2011‑12 Quick links

Supplementary information for 2011‑12 National Research Council Canada Departmental Performance Report can be found with the electronics links on this page. The financial statements and supplementary information form part of the NRC 2011‑12 Departmental Performance Report submission.

Highlights

NRC Strategic Outcome 1 – Advancements in Innovative Technologies and Increased Innovation Capacity in Targeted Canadian Industries and National Priority Areas

1.1 Program Activity: Manufacturing Technologies

In 2011‑12, work was continued on a cross-NRC initiative in alternative aviation fuels, including full scale flight demonstration on a Canadian grown biojet fuel. This continues to be an area of collaboration with the National Aeronautics and Space Administration (NASA).

NRC commissioned the wind tunnel to help aircraft manufacturers measure the noise levels generated by aircraft landing gear. Industry historically has focused on measuring and reducing the noise generated only by engines. Turbofan-powered airliners and business jets are becoming progressively quieter through the incorporation of higher bypass ratios, use of acoustic materials and nacelle design techniques. As a result the noise generated by the airframe, particularly the airflow turbulence around landing gear, wheel wells, flaps and slats, has become a target for noise reduction research.

NRC enabled coordinated access to its multidisciplinary expertise and state‑of‑the‑art facilities through partnerships with the manufacturing industry, Both consortiums and special interest groups (SIG) have industry groups who are partners in developing special technologies. The NRC also works actively with various stakeholder groups in order to properly assess all aspects of the implications of new research and technology.

NRC’s Centre for Surface Transportation has been collaborating with the Ottawa Police on the development of more environmentally friendly police cruisers. The average police car idles about 60 to 70 per cent of the time while on duty, guzzling 3.7 litres of fuel an hour. This adds to the wear and tear on the vehicles, forcing them to retire after about 160,000 kms. A new pilot project uses a spare battery in the trunk of police cruisers, to allow officers to turn off their vehicles while parked, but still use computers, radios, lights and heaters. This Greenfleet technology, designed with the help of NRC, aims to save fuel costs and reduce carbon emissions. The battery can be charged with a solar panel next to the emergency lights on the roof of a cruiser or by plugging it in at night. The plan is to outfit the system on 30 active cruisers by 2012, which would save about 270 kilograms of carbon emissions each hour those vehicles are parked while on duty. The Ontario Provincial Police is now looking into ways to adapt the technology to their vehicles.

Developing innovative high performance composite systems to protect critical concrete infrastructure against extreme shocks is the goal of a research project now underway at the National Research Council. NRC, in collaboration with industry and infrastructure owners, is conducting blast tests, simulating the effects of explosives and impacts from heavy vehicles on highway bridges, tunnels, data centers, power generation facilities and embassy buildings. The research objective is to develop protection systems that could provide high levels of performance in terms of shock absorption, load distribution, concrete confinement, and overall structural capacity. By enhancing the structural robustness of critical infrastructure, it is hoped that the risk of failure will be reduced. Project partners include BASF, the Department of Foreign Affairs and International Trade, the Department of National Defence, the RCMP, Transport Canada, and the University of Ottawa.

In Canada, current housing is not meeting the needs of some seniors and people with disabilities. Keeping people in their own homes as long as possible, and avoiding their premature admission to long‑term care facilities, will reduce healthcare costs and healthcare pressure on government. In collaboration with industrial partners, researchers at the NRC Institute for Research in Construction Centre for Computer-assisted Construction Technologies have been developing and testing smart home technologies to support independent living. The main objectives are to develop and integrate innovative information and communication technology (ICT) solutions and construction technologies. These are expected to provide high quality and yet affordable supports for seniors and people with disabilities to live safely and independently in their own homes. A proof‑of‑concept demonstration system has been implemented and deployed in two sites (at the NRC facility in London and at the iSILS facility in Waterloo). The prototype system is able to monitor air temperature and humidity, usage of water (washroom and kitchen), doors, refrigerator, stove, TV, motion, vital health conditions and location of the occupant. Caregivers (including family members) have password-protected access to this information on the Internet. Alerts are sent through emails, mobile text messages, and automatic phone calls. A test facility called Lab for Independent Living Technologies (LILT) is being built at NRC‑London facilities to further develop, test, and demonstrate the technologies developed by NRC and its partners.

Radio Frequency Identification to track construction materials – Finding accurate information on the status of materials is cited as one of the most common causes of non-productive time in construction projects. Materials are often misplaced or even go missing, resulting in countless hours spent searching for them. Sometimes they are never found. Since contractors are working on tight deadlines, missing components have to be re‑ordered or re‑fabricated, leading to additional costs and possibly penalties for late delivery. This can have a negative impact on productivity and project performance, and lead to problems with schedules, budgets, and quality. The application of information technology for tracking construction materials can provide an accurate and efficient means for reducing time and resources being spent collecting and managing data. In a recent example, the NRC Centre for Computer-assisted Construction Technologies (NRC‑CCCT), in collaboration with Armtec, a leading infrastructure and construction company, has developed a system for tracking precast tunnel liner segments manufactured in Armtec’s Woodstock, Ontario plant. The system relies on commercially available encapsulated Radio Frequency Identification (RFID) tags which, during the fabrication process, are embedded in the liner segments. As the segments move through the plant, their status (i.e., fabrication, quality, storage and shipping) and associated data are updated by the field crew using mobile computers. Armtec is using the system in its Woodstock plant to track the fabrication and inventory data for 58,000 tunnel liner segments being supplied for the York-Spadina subway extension project in Toronto, which involves construction of two 6.5 km tunnels. The system helps reduce time and resources spent locating concrete units in the storage yard and managing production and quality control data. Another key benefit of the system is that it generates the product handover documentation in electronic format that many asset owners are now requesting. Apart from helping reduce inefficiencies in the fabrication process, RFIDs and linked data in the tracking system also provide many benefits in the construction and maintenance phase. For example, the product handover documentation is currently used by Toronto Transit Commission (TTC) construction contractors working at the subway site to validate the materials received. In the long term, the embedded RFIDs and associated fabrication data will help TTC, as well as other infrastructure owners, to improve the maintenance and rehabilitation of a tunnel over its lifespan. The embedded RFID chips in infrastructure systems like bridges and tunnels have the potential to help owners to locate damaged pieces during operation and maintenance. The RFID‑based system offers significant advantages over the paper-based system, which is still the most prevalent method in the construction industry. While it provides all of the functionality of paper-based tracking systems, the RFID system has the added benefits of reduced user input time, faster data communication and fast record searching.

1.2 Program Activity: Information and Communications Technologies and Emerging Technologies

In response to the need for technologies to detect indoor air quality and deliver ventilation for dilution when needed, in support of Health Canada guidelines, NRC developed technologies to detect formaldehyde at parts per billion concentration along three platforms. The most promising platform employing conjugated polymers was built and successfully demonstrated. This unique approach enabled filing of both Canada and US patents, and NRC is currently negotiating licensing of the technology with two firms.

NRC researchers have developed PORTAGE, a software technology that allows a computer to translate text from one language to another, and to apply this capability to improve the productivity of human translators. To ensure that PORTAGE is competitive with the world's best translation systems, NRC participates in international evaluations of machine translation performance, including evaluations based at the National Institute of Standards and Technology (NIST). In a recent NIST evaluation, the NRC technology placed first overall in Chinese to English, and second in Arabic to English of sixteen competing technologies. These results have led to a new licensing opportunity. PORTAGE is already in use at eight Canadian universities and two commercial licences have been issued. The technology is having an impact not only on translation and terminology, but also second-language education and e‑business.

NRC Helps Grow Nanotube Industry – In February 2011, Raymor Industries installed and commissioned a new unit for the production of single-wall carbon nanotubes (SWNT) based on a technology jointly developed and licenced by the NRC and the University of Sherbrooke. NRC worked closely with Raymor to solve several problems associated with the powder feeder and to optimize the quality of the material produced. The work permitted improvements in the stability and reproducibility of the process which are key factors for the successful commercialization of SWNT. According to the Quebec-based company, the activities of Raymor in the field of production of SWNT have created 4 new full time jobs and have strongly contributed to the maintenance of 3 other full time jobs. Moreover, a recently acquired a US‑based Company involved in SWNT, NanoIntegris, has added another 3 employees. Raymor has embarked on commercialization efforts worldwide in order to become the global leader in the SWNT production. They now have distributors in South Korea, Japan and India and negotiations are underway for distribution agreements in Taiwan, China and Europe. A spokesperson for Raymor said, “We want to continue to have a strong relationship with NRC in many research projects for the future. We do think that we can have a huge impact for the Canadian economy within the next few years and make a central role for Canada in the field of SWNT.”

1.3 Program Activity: Industrial Research Assistance

NRCIRAP introduced several new performance management and reporting processes in 2011‑12.

  • In December 2011, new service standards were introduced, covering access, advisory services, project development, funding decision and payment. Clients are also now routinely invited to give feedback on NRCIRAP services.
  • A Business Process Review (BPR) was also launched, aimed to increase program effectiveness, efficiency, and balance, while providing field staff with more opportunities to interact with clients. The BPR workflow planning session done in March 2012 led to a better understanding of business processes, tools and information systems required to enhance program delivery and reduce complexity. The BPR recommendations will serve to help plan the implementation of the new tools and processes, which will be reported in 2012‑13.
  • The Post‑Project Assessment (PPA) is administered to all funded firms upon completion of their projects. Firms and NRCIRAP staff now log into a common site to complete the post‑project reports. Eventually this site will be expanded to include other online tools designed to facilitate the sharing of information between the firm and NRCIRAP. The data collected in the PPA measures the benefits identified by clients at the start of the project that would accrue as a result of NRCIRAP advisory services and financial support. The responses from the firm thereby provide feedback on the achievements and outcomes of NRCIRAP funded project.
  • The Status of Firm (SoF) and Impact Assessment (IA) are administered annually for up to five years after the completion of a funded project. The SoF collects metrics such as number of firm employees, VP expenditures, revenues from goods and services, etc. The IA collects data on the revenue derived from new products, the impact of new processes, the social benefits achieved, etc.

Over the coming years, the data collected from these tools will allow NRCIRAP to measure the long-term success of stimulating innovation capacity, as well as the adoption or commercialization of technology-based products, services or processes for NRCIRAP-funded SMEs.

NRC-IRAP, Program of Choice – Because of its extensive networks and skilled Indutrial Technology Advisors (ITAs) in the biomedical industry in Canada, NRCIRAP was chosen to deliver the Canadian HIV Technology Development Program, which is funded through Industry Canada in relation to the Canadian HIV Vaccine Initiative and the Bill & Melinda Gates Foundation. The objective of the NRCIRAP CHTD Program is to actively encourage and support the participation of SMEs (Incorporated firms with 500 or fewer employees and who are currently involved in some research or technology related to HIV) in the development of an HIV vaccine and other technologies related to the prevention, treatment and diagnosis of HIV. In 2011‑12, the first year of program delivery, NRCIRAP approved 11 IRAPCHTD projects with approximately $4M in multi‑year commitments, and actual expenditures of $1.17M. This Program represents a significant Canadian contribution to global efforts to develop a safe, effective, affordable and globally accessible HIV vaccine.

NRCIRAP partnered with Public Works and Government Services Canada (PWGSC) under the Canadian Innovation Commercialization Program (CICP), a pilot initiative announced in Budget 2010. CICP is part of the Government of Canada’s commitment to promote Canada’s economic growth, bolster innovation in Canada’s business sector, and help companies bridge the pre-commercialization gap for their innovative products and services. During 2011‑12, NRCIRAP continued to co‑develop the Program delivery process with PWGSC, and provided independent reviews of 336 proposals during the second CICP call for proposals. The CICP was recognized by the Government of Canada as a key contributor to innovation and was made permanent in Budget 2012 and NRCIRAP expects to continue to partner with PWGSC.

NRCIRAP’s success stems from its track record of customized services and the highly skilled field staff that deliver those services across Canada. Its ITAs are a unique resource, the focal point of one‑on‑one and trusted relationships with companies that extend for years. ITAs provide individualized and adapted services to each firm’s unique attributes and requirements in order to provide a tailored response to their technical and business development needs. Because of this comprehensive support, NRCIRAP clients are better equipped to perform research and development (R&D), commercialize new products, processes and services, and access new domestic and international markets. A number of success stories related to NRCIRAP support are presented below.

Making technology and business advisory services more accessible – Simon Fraser University (SFU) created the Technology Business Mentorship Program (TBMP) in 2005‑06 to assist local start‑ups from Surrey and the Lower Mainland by providing business advisory services. This program provides a place where firms can turn to, beyond the assistance of their technology managers, for insight and feedback on their business. At the beginning of this project, SFU turned to NRCIRAP for financial assistance and advisory services since the Program is well known in the community with expertise in technology and business, and has access to a nationwide network of advisors across all industry sectors. "Support from IRAP has been critical in allowing SFU to develop this program, which cannot be supported by our base funding," explains Mike Volker, Director of SFU’s Innovation Office. "The benefits to the client firms have been demonstrated, and SFU has earned a reputation in the community as an innovative and dynamic institution." In 2011‑12, four firms received assistance from the TBMP and two of them came from NRCIRAP referrals. Since the creation of TBMP in 2005, 46 companies have gone through the Program and approximately 16 of those companies came directly from NRCIRAP referrals. These achievements could not have been met without the assistance of NRCIRAP and its advisors.

Leading the market through innovation – Axiom Group Inc. offers design, development and production services for the plastics, electronics and consumer industries. In 2004, three NRCIRAP ITAs helped Axiom develop the One‑Piece Moulded Filter and Screen Technology. During the project, Doug Reed, an ITA, offered technical advice suggesting that they look into bringing the process flow modeling in‑house. Doug advised the firm to adopt modeling capability in‑house, and eventually, the One‑Piece Moulding Filter project brought Axiom from a tier‑two supplier (selling components to larger companies, and then the final clients) to a tier‑one supplier (selling components directly to the final client). This initiative alone contributed to a $3M increase in sales. Also, Axiom increased their revenues by $1M and its technical knowledge which is a direct result of bringing the process flow modeling in‑house.

From the incubator to the big leagues – Xenon Pharmaceuticals Inc., a clinical genetics-based drug development enterprise, was spun out of the University of British Columbia (UBC) in 1996. By 2002, the company was ready to leave the UBC incubator, and in 2003, made an important discovery identifying a drug target related to pain. Because of the nature of the business, Xenon’s success is measured by its ability to attract investments and partnerships that enable it to continue and further its research. "Our ITA, Paul Barran, has been a great spokesperson for Xenon. His continued willingness and flexibility to approach us about opportunities have been tremendously helpful," said Robin Sherrington, Vice‑President, business and corporate development at Xenon. Since 2003, NRCIRAP’s involvement with Xenon:

  • Helped it attract other partnerships;
  • Resulted in discoveries that have supported more than $30M in investments;
  • Increased its intellectual property portfolio, with multiple patent applications;
  • Supported the discovery of XEN402, now in clinical development;
  • Enabled its potential for new spin‑off drug discovery programs.

In January 2012, Xenon announced a strategic alliance with Genentech, a member of the Roche Group, to discover and develop compounds and companion diagnostics for the potential treatment of pain. Under the terms of the agreement, Genentech has an exclusive license to compounds and a non‑exclusive license to diagnostics from Xenon for development and commercialization of products. Xenon will receive an undisclosed upfront payment, research funding and is eligible to receive research, development and commercialization milestone payments, totaling up to $646M for multiple products and indications. This deal is a direct result of Xenon’s pain platform which IRAP helped to initiate at Xenon.

Taking lightweight composite product manufacturing to a new level – Launched as a one‑person consultancy in 1997, Profile Composites Inc. now employs 10 people in Canada, and recently announced the opening of a second location in the U.S. that will employ another 15. The firm designed its first product – composite floats for small airplanes – for Seaflight Industries Inc. with help from NRCIRAP and the NRC Institute for Aerospace Research. Since then, it has gone on to manufacture a variety of products, including wind‑turbine blades, satellite dishes, drones, auto and truck bodies, fuel tanks and kayak paddle shafts.

NRCIRAP worked with Profile on a variety of VP innovation and Youth projects and provided them with advisory services. Without NRCIRAP timely assistance, the firm would have moved to the United States. Through NRCIRAP’s involvement and financial support, Profile has:

  • Evolved from a one‑man consultancy to a manufacturer with 25 staff in two locations;
  • Attracted 40 customers, half of whom came by referral through NRCIRAP;
  • Doubled its revenue from sales in the past four years;
  • Joined CCMRD and begun joint manufacturing research for aerospace manufacturing technology with Boeing and Bell Helicopter.

HIV vaccine research gets funding boost from federal governmentNRC provided financial contribution to Sumagen Canada Inc. for up to $1.014M to partially support the Phase I human clinical trials for which a HIV new vaccine recently has been approved. The vaccine uses a genetically modified killed whole virus to stimulate strong immune response against the virus. Human testing, however, is extremely expensive. Dr. Chil Yong Kang, Sumagen's Chief Scientific Officer, stressed the most beneficial thing about the grant was its recognition of his project’s potential worth. “This is further proof of support for our ideas. We’ve gotten approval from the United States Food and Drug Administration and now we’ve gotten support from the government of Canada—that means this project has merit. That’s why it’s important to have individual assessment of programs such as these,” Kang said. “It’s not the amount of money that really matters, but rather the approval for our project from the experts and the government that’s significant.”

1.4 Program Activity: Health and Life Science Technologies

NRC continues to draw companies to its clusters, such as Immunitor Inc. (which has established interactions with several private and public entities in the vibrant Charlottetown biotechnology cluster, and will relocate some of its activity to the cluster to enhance its vaccine collaboration with NRC) and OmniActive Health (housed in Charlottetown Industry Partnership Facility while awaiting the opening of its functional ingredients VP centre in the PEI BioCommons Research Park). The Prairie Gold industrial partners (Agrisoma Biosciences, Inc., Linnaeus Plant Sciences Inc. and Metabolix Canada), benefited from their proximity to the Saskatoon plant biotechnology cluster as residents of the NRC Saskatoon Industry Partnership Facility, enhancing their collaborative effort with NRC and others to produce biofuels from carinata.

Cancer biotherapeutic developed with NRC – An NRC discovery is playing a key part in what may prove to be a much more effective way to treat one of the most serious types of cancer. The new drug candidate being developed by Helix BioPharma of Aurora, Ontario, harnesses the power of antibodies, molecules produced by the human immune system to fight off infectious diseases, to attack cancer cells. Anticancer drugs can be attached to antibodies with specificity enabling them to be specifically targeted to tumours, reducing unwanted side effects and increasing the chances that the drug will destroy all of the tumour cells.

Transfering technology from the bench to clinical use – More than twenty thousand women are diagnosed with breast cancer each year and 5,100 die. A very effective drug (Trastuzumab), introduced several years ago, may be associated with cardiac dysfunction and congestive heart failure (CHF). The detection of trastuzumab-induced cardiotoxicity has been difficult until NRC, in collaboration with cardiologists in St. Boniface General Hospital and oncologists at CancerCare Manitoba, demonstrated that tissue velocity imaging and strain imaging are sensitive, non-invasive, and cost-effective echocardiographic techniques that allow early detection of the drug-induced cardiac dysfunction. As a result of this work, all breast cancer patients in Manitoba are now monitored closely for heart dysfunction once they are treated with trastuzumab.

NRC continued its collaboration with Ceapro Inc. to generate mechanism‑of‑action data of bioactive properties to support the sale of the company’s Canadian ingredients targeting anti‑inflammation, anti‑allergens, wound healing and personal care products for anti‑aging. NRC also completed synergistic studies combining Ceapro ingredients with rosehip extracts with preliminary data pointing to multiple potential product candidates for the company. Ceapro and NRC will further evaluate rosehips native to Prince Edward Island, for new products of benefit to Canadian agricultural producers.

Development of companion diagnostic testsNRC is in negotiation with two Canadian companies to licence a Multiple Survival Screening (MSS) algorithm developed at the NRC, which provides a robust set of predictive markers which can accurately identify breast cancer patients who will not respond to treatment with Paclitaxel (Taxol), a commonly used chemotherapeutic agent, to which only 20% to 30% of patients positively respond. The NRC-developed marker sets were effective in predicting unresponsiveness in ER+ datasets with 95% to 97% accuracy, and effective in predicting unresponsiveness in ER- datasets with 88% to 91% accuracy. The technology, would lead to improved patient outcomes by allowing the physician to select alternate chemotherapeutic agents, thereby optimizing treatment early.

Cancer biotherapeutic developed by NRC enters preclinical trials – Montreal-based Alethia Biotherapeutics is conducting pre‑clinical trials of new treatments for breast, prostate, ovarian and other forms of cancer, using antibodies developed by NRC researchers – AB‑16B5 in particular, a humanized IgG2 monoclonal antibody discovered by NRC and licensed by Alethia, which targets secreted clusterin for the inhibition of cancer-associated epithelial-to-mesenchymal transition (EMT), and has shown positive pre-clinical results in representative cancer models derived from various solid tumours. In June 2011, Alethia entered into an agreement with Goodwin Biotechnology to produce the antibody for formal preclinical trials. Batches of the antibody manufactured by Goodwin were used by Alethia for preclinical trials throughout 2011. Then in November, the company announced that AB‑16B5 inhibits the growth of human tumours by abrogating their ability to undergo EMT, which renders tumour cells more responsive to chemotherapy. NRC continued to help Alethia reach its commercialization goals through a collaborative agreement to develop and optimize a method for quantification of target peptides in plasma using solid‑phase extraction for the development of companion diagnostic tests; characterization of peptides that will be used to develop companion diagnostic tests; and informal preclinical testing of several antibodies developed either by Alethia or NRC, which will be undertaken in the near future.

biOasis Receives Verification That Transcend Localizes To a Number of Cell Types in the Brain – biOasis Technologies Inc., a Vancouver-based biopharmaceutical company developing products for the diagnosis and treatment of neurological diseases and disorders, is currently developing CognitestTM, a blood test for the diagnosis of Alzheimer's disease and Transcend, a proprietary molecular carrier intended to transport drugs across the blood-brain barrier (“BBB”) for the treatment of a wide range of neurological, oncological and infectious disease applications. The company worked with NRC to obtain a proof of concept that Transcend can carry fluorescent dye molecules across the blood brain barrier and distribute them in neurons and astrocytes. Within these cells Transcend was localized to a variety of intracellular structures, including lysosomes. This is further evidence that Transcend has the potential to deliver a variety of therapeutic agents of small and large molecular weight across the blood-brain barrier and into cells within the brain, which could enable the treatment of neurological conditions that have, for the most part, gone untreated. NRC will continue to produce materials for preclinical studies and conjugation to a range of small molecule and biologic therapeutics and also help the company on implementing and validating, CognitestTM as a companion diagnostic test in Alzheimer disease studies. Validation of CognitestTM in these studies will accelerate entry of company’s lead biologic targeting Alzheimer’s disease into clinical trials and will enable selection of patients that are likely to respond to the treatment.

Validation of Zymeworks’s propriety platforms for designing antibody variants – In September 2011, Zymeworks announced the completion of a financing round totaling $8.1M. The financing consists of a follow‑on round of institutional investment by CTI Life Sciences Fund, L.P. (CTI), as well as a new investment by Advanced Biotechnologies Venture Fund (ABVF) and investments by several existing private shareholders. Zymeworks is using the proceeds to advance its AzymetricTM and AlbuCORETM platforms, as well as the development of Zymeworks’ best‑in‑class protein therapeutics pipeline in the areas of cancer, autoimmunity and inflammatory diseases.

Zymeworks was also featured in scientific journals Nature Reviews Drug Discovery and Genetic Engineering News for the development of its AzymetricTM antibody platform for bispecific therapeutic applications. A deal with Merck as well as CTI’s financing have led Zymeworks to massively expand the amount of collaborative work performed by NRC: contract values escalated from about $50K per year in 2009 to over $1M presently. NRC will remain one of Zymeworks’s key partners as development of these platforms and the associated antibodies continues.

New Life for Old Drugs – ApoPharma Inc and NRC have recently entered into a new 2‑year agreement to build upon previous 4‑year VP collaboration ($3.03M) to reposition the FerriproxTM family of molecules as therapeutics for neurodegenerative diseases, such as Alzheimer’s and Parkinson’s disease. Apotex Inc. was founded in 1974, and is the largest Canadian‑owned pharmaceutical company, producing more than 300 generic pharmaceuticals in approximately 4,000 dosages and formats which, in Canada, are used to fill over 85 million prescriptions a year in Canada. Although the company’s core business is in developing and manufacturing generic pharmaceuticals, ApoPharma Inc, an VP division of Apotex, carries out VP on new chemical entities in the areas of hematology, neurodegenerative diseases and psoriasis. Apotex's first innovative drug, FerriproxTM is approved in over 50 countries for treating iron overload in Thalassemia.

In a 4‑year collaboration with the company, NRC demonstrated that Apotex's lead compounds significantly improve cognitive performance of transgenic animals affected with Alzheimer`s‑like loss of memory. Furthermore, the compounds were able to reduce accumulation of the toxic protein, amyloid beta, in the brain of these mice. These and other batteries of pre‑clinical studies performed at NRC enabled company to select lead candidate for the indication. New VP agreement with the company signed in March 2012, will engage NRC expertise in evaluating efficacy and mechanism of action of these clinically used molecules in pre‑clinical models of Parkinson’s disease. The strategy of drug re‑positioning used by the company reduces drug development cost and enables cheaper and readily‑available drugs on the market.

In May 2011, NRC signed a one‑year contract with the Prairie Isotope Production Enterprise (PIPE) – a consortium including Acsion Industries, the Winnipeg Health Sciences Centre, and the University of Winnipeg – to produce molybdenum‑100 using a linear electron accelerator. The wordwide shortage of the commonly used medical isotope molybdenum Mo‑99, in short supply since 2007, is a growing concern nationally and globally. For NRC, this has created an opportunity to contribute to a project of national importance: replacing present methods of medical isotope production with far less expensive alternatives. Several designs were proposed and tested with NRC simulating these various designs, together with their water-cooling systems, to determine temperature distributions throughout the assembly.

Taking a brainwave to market – A device known as the Halifax Consciousness Scanner from Mindful Scientific Inc. is the brainchild of Dr. Ryan D’Arcy, the lead investigator with the NRC in Halifax. Together with Dalhousie University colleagues Dr. Don Weaver (neurologist), and Chris Barden (chemist-turned-entrepreneur), they are working to develop a portable scanner that can be used to take on‑the‑spot brain-function readings anytime an athlete experiences a head trauma. The new device will help protect athletes from the consequences of concussions. The scanner measures five key aspects of brain function: sensory response, perception, attention, memory, and language. In less than five minutes, even a miniscule drop in brain function will alert coaches and athletes if there has been any change to the athlete’s brain status. Weaver and D’Arcy are currently using a scanner prototype to assess brain function in patients with severe trauma‑ or stroke‑induced brain injury and working with engineers to transform the hardware into an easy‑to‑use handheld unit. The Mindful Scientific team has joined forces with a minor hockey team and a National Hockey League team to gather baseline brain-function measures and post-concussion measures from players who hit their heads throughout the 2011‑12 season. In addition, the company was chosen as one of the top three medical technology companies in North America by the prestigious LifeSciences Alley Conference and Expo in Minneapolis. It’s anticipated that Mindful Scientific will be ready to begin producing the Halifax Consciousness Scanner commercially by the end of 2012.

NRC led pre-clinical tests to support Island Abbey Foods Ltd’s product launch of Honibe® Honey LozengesTM with eucalyptus and menthol. The product is now available to Canadian consumers at pharmacies and grocery stores. NRC also conducted contract quality assurance and quality control tests for regulatory compliance of Abbey’s natural health products.

Chemaphor, an SME NRC Industry Partnership Facility tenant and collaborator received National Animal Supplement Council certification for its OximunolTM chewable tablets and other companion animal products based on technology initiated in NRC labs. David Hankinson, CEO of Chemaphor, said "This achievement of an order for product is a major milestone in Chemaphor's strategy to expand into the International market with products that can improve the quality of life for companion animals. We are pleased by the size of this first purchase order and are excited that OximunolTM Chewable Tablets, which has been so well-received by dog owners in the Canadian market, finally will become available to dog owners in the US through their veterinarians." Dave Hankinson also added, "This is a great first step in our international commercial efforts and brings our investors validation of demand for our OximunolTM Chewables, while we seek distribution agreements in other territories and also aim to bring follow-on products to market."

In late 2009, Triffid flax (a banned genetically modified variety) was detected in Canadian flax imports to Europe. The EU immediately halted Canadian flax imports, resulting in farmers’ inability to move inventory, prices plummeting, and exporters holding cargo in limbo. NRC, the Flax Council of Canada, the University of Saskatchewan Crop Development Centre and Quantum Diagnostics worked closely to develop a test to identify the presence of CDC Triffid gene sequence in seeds, which enabled producers to definitively determine that their seed lots were clear of Triffid. This testing has allowed the industry to rebound and re‑open important agriculture exports.

Nanocrystalline Cellulose (NCC)NRC developed a unique patented process (PCT Appl. CA2010/000372, 2011 ), which is easily scaled‑up, to convert diversified biomass including wood pulp and plant fibers into carboxylated nanocrystalline cellulose (NCC) using a versatile one‑pot chemical procedure. Recent process development work has demonstrated the scalability of the process (currently 10 kg NCC per batch). NRC has licensed this technology to BioVision Tech., a Canadian company, for the scale‑up and production of NCC from Canadian biomass for $800k. A number of industrial collaborations are being set up with them to develop applications including superinsulating aerogels, NCC‑antimicrobial products, high performance NCC‑reinforced plastic foams, NCC‑reinforced polyurethane for automobile parts, as well as NCC thermoplastic starch materials for packaging.

In addition, NCC is also being investigated for bioapplications such as drug delivery and antimicrobial coatings to prevent hospital associated infections (as part of the potential NRC nosocomial program and drug delivery program). Successful deployment of NCC-based materials will provide opportunities to various Canadian companies and our licensee to commercialize innovative high-value products.

1.5 Program Activity: Energy and Environmental Technologies

The use of enzymes to replace traditional chemical processes to produce, for example, fibres and other value added biopolymers, yields lower net CO2 emissions, lowering overall water usage and energy consumption. NRC scientists have developed a proprietary biocatalyst to produce high quality natural biofibres that can be used to develop biocomposites to replace other commercial products, such as fiberglass.

Kraft Lignin in Phenol-Formaldehyde Wood Adhesives – North American pulp mills are becoming increasingly interested in expanding the use of lignin, a co‑product from kraft pulp mills currently burned to produce heat and power and to recover pulping chemicals. NRC and FPInnovations (FPI) developed lignin-containing phenol-formaldehyde adhesives for use in the manufacture of plywood and oriented strand board (OSB). The currently used adhesive resin is a phenol formaldehyde derived from petroleum oil. With the rising prices of crude oil, a replacement by a natural based raw material has become paramount. NRC and FPI demonstrated that kraft lignin, a renewable, non-toxic, commercially available and low costing resource, can replace 30% of the phenol used to make phenol-formaldehyde resin. A major Canadian industrial producer of phenol-formaldehyde resins has recently validated the lignin substitution results. Based on its own favourable economic analysis, it is keen to proceed to commercial trials and implementation. The availability of lignin at commercial scale will underpin both the PF-resin application as well as other new applications in a range of sectors for this abundant natural polymer. The potential market for lignin‐based products is massive; lignin can be used as a green alternative to many petroleum‐derived substances, such as fuels, resins, rubber additives, thermoplastic blends, nutra‐ and pharmaceuticals, etc. Further, a life‑cycle assessment shows that the substitution of kraft lignin for petroleum-based phenol in plywood and OSB can be environmentally preferable in a majority of impact categories, most notably in regard to consumption of non-renewable resources and effects on climate change.

The current explosion in next-generation sequencing technology enables the characterization of microbial community structure and function at a level of detail not previously possible. NRC is using this technology to monitor microbial communities involved in the degradation and remediation of hydrocarbons in soil and groundwater, toxic cyanobacterial blooms, and wastewater treatment systems to improve treatment approaches to water quality. These sequencing technologies were applied for the first time to provide insight on the bacterial communities involved in the degradation of hydrocarbons in contaminated sites under the extreme conditions encountered in the Canadian high Arctic, enabling NRC researchers to develop and apply the most effective treatment solutions under the extreme conditions of low temperatures and low water activity, and to monitor on site bioremediation performance.

NRC scientists have also developed microarrays and bead-based assays to detect pathogenic bacteria in water and foods, to monitor waste treatment processes to ensure the removal of pathogens and to perform fecal source tracking to detect pathogens in surface water bodies. These techniques are ensuring that specific potential pathogens are detected and that improved detection sensitivity are integral parts of future water quality monitoring capabilities.

NRC also developed scalable approaches for producing microalgae biofuels using industrial waste streams, including CO2 from flue-gases and nutrients (N, P, and trace metals) from municipal and industrial wastewaters. In 2011‑12 NRC established specialized facilities for mixing, delivering and measuring specific industrial flue gases for selecting tolerant algae strains, and additional algal cultivation apparatus specially designed for growth experiments using wastewater treatment plant effluent as a nutrient source. Through collaboration with NRC, Solutions4CO2 (S4CO2), a Canadian SME, successfully demonstrated the superiority of its CO2 infusion systems, enabling a 5‑fold more efficient delivery of CO2 for algal growth than traditional aeration methods, for intense cultivation of microalgae. As a result S4CO2 has developed commercial relationships with industry partners in the algal cultivation field and has attracted private investment to further its product development.

The NBP4 initiative has successfully engaged industrial partners committed to the development of technologies critical for the successful commercialization of microalgae biofuels

To develop a viable agro-industrial Canadian value chain from flax/hemp fibres to biocomposites, NRC established an industrial alliance among the biomass producers from Quebec, Saskatchewan and Manitoba; the 1st transformation straw processors (SWM, Biolin, Écosphère, Lanaupôle Fibres); the 2nd transformation non-woven and woven manufacturers (Texel, Régitex, JB Martin); and the composite manufacturers and OEMs. Now, for the first time, Canadian flax fibres from an oilseed cultivar are being processed and transformed into comingled flax fibre roving or mats (Régitex and Texel) for automotive applications. Prototyping activities with our industrial partners are continuing.

As a result of this work, a QC‑based organization (Lanaupôle Fibres), which promotes the cultivation and transformation of industrial hemp, received $1.1M from DEC‑QC in April, 2012. Another NRC major Canadian industrial partner negotiated a (preliminary) licensing agreement for the use of a Linase (NRC proprietary enzyme) and a biotreatment process, enabling it to receive $1.9M from Sustainable Development Technology Canada (Round 18, 2011) for the scale‑up of a bioprocess to produce textile grade flax/hemp fibres.

In addition, technologies to improve the mechanical performance of natural fiber composites as well as their fire resistance were developed and applied successfully in interior aircraft components. These important accomplishments are now underpinning two multi-partner projects (SWM, Texel, JB Martin, Régitex, Marquez Transtech, AS Composites, Bombardier Transport, Bombardier Recreative, Composite BHS, Composites VCI, Sigma Venture, Delastek and Prévost Car) that will facilitate the introduction of Canadian natural fiber composites in the automotive and construction industries.

Polyurethane (PU) rigid and flexible biofoam formulations with 10% lignin were successfully developed providing industry with a solution for non‑food grade biofoam with characteristics similar to traditional foams. The technology was transferred to a Canadian insulated foam producer, which is collaborating with a Canadian lignin producer, Tembec, to fabricate the first generation of insulated spray foams and PU foam panels from Canadian lignin.

An NRC‑developed blending technology enabled lignin replacement of up to 20% of thermoplastic polypropylene. This lead to two successful industrial projects with FPInnovations and Lignol on the evaluation of the potential of Canadian Kraft and organo‑solv lignins, respectively, in thermoplastic blends. These developments, and others at NRC and our industrial partners, have opened new doors for the valorization of Canadian lignin in the multi-billion dollar thermoplastic markets.

To improve water quality, NRC developed micro-arrays, bio-assays, and biosensors to track and detect pathogens and other microorganisms in drinking water sources including surface and groundwater. For instance, in water and contaminated site monitoring, NRC scientists used next-generation sequencing technology to apply effective treatment solutions to contaminated sites in the Arctic by monitoring and treating bacterial communities involved in the degradation of hydrocarbons. In addition, NRC scientists have developed techniques to detect disease-causing bacteria in water and foods, to monitor waste treatment processes to ensure the removal of these pathogens, and to perform procedures to detect pathogens in surface water bodies. The NRC also developed an electrolysis-enhanced anaerobic digestion process to convert wastes into methane for a more efficient net energy production.

As part of a comprehensive process to treat wastewaters, an electrolysis-enhanced anaerobic digestion process was developed at NRC to efficiently convert waste into the biogas, methane. Use of this technology results in net energy production while consuming organic wastes and may be more efficient a process than producing biodiesel or ethanol from waste.

Water management and sustainability (as well as renewable energy in both solar and biofuel areas) are expected topics of continued discussion at the second Canada-Israel Innovation Roundtable in 2011.

NRC Strategic Outcome 2 – Canadians have access to research and development information and infrastructure

2.1 Program Activity: National Science and Technology Infrastructure

Astronomy contributes to the development of highly skilled personnel by reaching out to young people and by training highly qualified people in general skills such as the ability to solve complex problems, perform research and develop technical skills. A key finding of the Astronomy in Canada Footnote 1 report was that astronomy enrolments across Canada are increasing, astronomy post doctoral fellows have doubled since 2000, and tenure track positions are up by 70%. In line with “promoting world class excellence” Canadian astronomy has been found to rank highest in impact of any country in the G7. And through its international telescope agreements, astronomy encourages global collaborations that benefit all participants including industrial partners.

As part of its mandate, NRC provides access to primary international state-of-the-art telescopes for Canadian scientists, as well as to astronomical data that are collected and distributed by the NRC’s Canadian Astronomy Data Centre. The central driver for ongoing development activities is the community-based Long Range Plan for Canadian Astronomy, a decadal plan referred to as LRP2010. This plan is focused on securing Canada’s participation in large-scale “world observatories” that are intended to form the future national infrastructure for Canadian astronomy and which speaks to Canadian strengths. In 2011‑12, early science operations began at one of these next-generation facilities: the Atacama Large Millimetre Array (ALMA) in Chile. In spring 2012, NRC formally joined the international SKA Organisation in order to participate in the pre-construction of the Square Kilometre Array, a global project involving 20 nations which is a key priority for the Canadian research community. NRC will continue to contribute to the Canadian portfolio of ground-based observatories, including creating leading-edge instrumentation for the facilities in collaboration with Canadian industrial partners.

In February 2012, the International Astronomical Union announced that six minor planets would be named for NRC scientists in recognition of their contributions to the field of astronomy. David Bohlender, David Crampton, Eric Chisholm, Greg Fahlman, Peter Stetson and Ken Tapping each have a minor planet bearing their name in the asteroid belt between Mars and Jupiter.

Dr. David Crampton of NRC was awarded the 2012 Carlyle S. Beals Award by CASCA in recognition of outstanding achievement in research. A leading scientific and technical figure in the Canadian astronomical community for more than 40 years, Dr. Crampton's past honours and distinctions include the BC Science Council Gold Medal (1983), the Astronomical Society of the Pacific Muhlmann Award (1991), and the Commemorative Medal of the Golden Jubilee of Her Majesty Queen Elizabeth II (2002). Dr. Crampton’s work has formed the basis for a wide range of ground-breaking instruments for Canadian telescopes, including the CHTD Herzberg Spectrograph, the Multi-Object Spectrograph and its near-Infrared upgrades, the Mosaic Camera, Adaptive Optics Bonnette and MegaPrime, as well as the Gemini Multi-Object Spectrograph (GMOS). Literally hundreds of astronomers have used the Dominion Astrophysical Observatory, Canada France Hawaii Telescope, and Gemini telescopes to publish thousands of articles based on data collected with these instruments.

Astronomy contributes to the development of highly skilled personnel by reaching out to young people and by training highly qualified people in general skills such as the ability to solve complex problems, perform research and develop technical skills. A key finding of the Astronomy in Canadareport was that astronomy enrolments across Canada are increasing, astronomy post doctoral fellows have doubled since 2000, and tenure track positions are up by 70%. In line with “promoting world class excellence” Canadian astronomy has been found to rank highest in impact of any country in the G7. And through its international telescope agreements, astronomy encourages global collaborations that benefit all participants including industrial partners. The Report also notes, “Canadian astronomy has arisen to become one of the country’s research success stories. Such successes include a world renowned research community that has been recognized through numerous top awards and whose work has become among the most highly cited astronomy research in the world; an internationally recognized capability for developing pioneering astronomy technologies; and not least, a reputation for being a leading contributor and partner to some of the most influential observatories”. NRC has played a critical role in this success through “its in‑house expertise in adaptive optics, millimetre instrumentation and correlators, (developing)… an international reputation for its ability to design and develop, in collaboration with industry, critical telescope technology”. Through its economic analysis, the study found that expenses incurred by the Canadian government on observatories are approximately equal to the quantifiable economic impacts for the country, which are in addition to the notable unquantifiable social benefits.

NRC has developed a new on‑site measurement service for Canadian electrical utilities. As power cables age, their insulation deteriorates and local defects such as voids and impurities become more active. The new measurement technique evaluates the overall conditions of the insulation of the power cable and can be performed on‑site on de‑energised cables with the collaboration of electrical utility staff. The entire test takes no more than 5 minutes after the cable has been removed from service. If measurements indicate that a cable only has localized problems, the cable can be repaired and returned to service. However, if measurements show that the overall properties of the insulation of the cable are in poor condition, the cable should be replaced. So far more than 260 power cables have been measured during the winter months of 2011‑12 with NRC’s client, Hydro Ottawa. The results of the measurement program are used by Hydro Ottawa to plan its cable replacement program for the next construction season. Many other electrical utilities in Ontario have shown an interest in this new NRC capability.

In addition, NRC is establishing measurement standards for emerging technologies such as nanotechnology, biotechnology and ICT. Robust manufacturing practices coupled with the necessary standards and measurement infrastructure deliver economic impacts as industry begins to bring early products to the global marketplace.

Researchers from Ryerson University and Nemak Inc. are using neutron beamlines at CNBC as part of an AUTO21 project to improve reliability of light weight vehicle engines, which are needed to increase fuel efficiency and reduce greenhouse gas emissions. AUTO21 is funded by the Networks of Centres of Excellence program. Neutrons were used on aluminium engine blocks to measure stress, which can be a life-limiting factor of the engine. The neutron data provided clear evidence that the stress can be reduced using an advanced production method that actively chills the aluminium after being poured into the mold. This success has led to an expanded second phase of the project with additional collaborators, including researchers from General Motors Canada and CANMET Materials Technology Laboratory. Phase 2 of the project will develop advanced methods to address the properties of aluminium affecting its performance, including residual stress, stability, strength and reliability.

CNBC Researcher awarded Order of Canada – Dr. William J.L. Buyers was appointed an Officer of the Order of Canada in June 2011 for his contributions to condensed matter physics especially in the field of magnetism. Since his arrival in Canada in 1965 as a post-doctoral fellow at NRC, Dr. Buyers has been in the forefront of work on highly correlated electron systems. His early work was pivotal in establishing the nature of spin waves and crystal field excitations in magnetic materials. He also played a leading role in the field of quantum magnetism, and his work led to the first observation of the "Haldane Gap" in the spin spectrum of a spin‑1 antiferromagnetic chain compound, which confirmed the highly controversial speculation postulated by theorist D.M. Haldane. Although he retired from his position as a principal research officer at NRC in 1995, Dr. Buyers has retained an active research program as a visiting scientist at the NRC‑CNBC, as well as at the Canadian Institute for Advanced Research.

In a project relating to nuclear medicine, TRIUMF’s Paul Schaffer received a Strategic Opportunities Fund award from GenomeBC to lead a team working on antisense PET imaging of mRNA expression, a project that will develop a novel class of antisense oligonucloetide-based molecular-imaging agents for the diagnosis and characterization of disease.

Building on their first success with heavy-metal targets, TRIUMF accelerator physicists and nuclear scientists set a new world record for total beam power on an actinide target and conducted four difference pioneering physics experiments using rare, heavy isotopes of astatine and francium.

2.2 Program Activity: Scientific, Technical and Medical Information

NRC’s STM information program provided information to support evidence-based decision-making that ensured that research is going in the right direction. Services such as Strategic Technical Information Analysis synthesize large amounts of information from various sources into concise information on which to base decisions. Skilled information specialists ensure that the best information is used as input into reports to increase the likelihood of effective decision making. The information discovery and document delivery services ensured that information in the published literature was available when it was needed to researchers and decision-makers alike. Repositories like NPArC and PubMed Central Canada made research outputs from NRC and the Canadian medical research community easily available to support further research and innovation.

Consult NRC’s web site for a full description of services offered by NRC Knowledge Management.

The following Program Activity supports all strategic outcomes within this organization

Internal Services

NRC implemented the first year of its five-year Investment Plan. The new governance structure and associated integrated investment planning process to assess risk and prioritize investment requirements has been put into practice as detailed in the plan that was approved by Treasury Board on March 24, 2011. NRC planned to undertake 27 projects totalling $32.5M of which $21.6M was capital in year one of the investment plan. NRC’s focus for the first couple of years of the Investment Plan was to invest in existing assets that support core research and development activities, in particular rust‑out issues related to real property, scientific equipment, laboratories and information technology assets.

The actual number of investment projects started in the first year was 31. The focus remained as planned on existing assets. The actual expenditures for 2011‑12 were $15.2M Capital and $2.1M other funding (operating and salary budgets). The capital expenditures were lower than planned due to project approval delays of the first year of the new governance implementation. The governance process is now well established and 2012‑13 is starting well with all investment projects having expenditure authority approval.

The governance of investment planning is 100% aligned with NRC’s Project Approval Authority Directive. It is transparent and effective, with clear and appropriate accountabilities.

Based on the new hiring services model implemented in 2011‑12, a feedback survey for hiring managers was launched in 2011‑12 to obtain direct feedback on services. Overall, a 96% good/excellent level of satisfaction was reported by clients and the insight from the feedback has helped shape tools and processes.

As part of the ongoing effort to streamline hiring and better support clients, a collaborative review of the hiring workflow was initiated in 2011‑12 to identify and address key challenges. The review resulted in more consistent practices, better communication with stakeholders and the development of new methods and tools to support a more streamlined approach.

To further increase effectiveness and efficiency, a project team was established in 2011‑12 to prioritize, document, streamline and standardize the top 50 common client services work processes.

In 2011‑12, NRC also reviewed and revised its hiring policy and accompanying procedures resulting in an increased emphasis on intent, clear roles and accountabilities, and a move from joint delegation to management owned hiring delegation. Updated guiding principles provide an ethical framework to guide management decision making while providing hiring managers with increased flexibility in meeting their hiring needs.

Additionally, several recruitment programs, both internal to NRC and on an international level, were reviewed in 2011‑12 to assess their strengths and weaknesses in how they are meeting the needs of the new NRC. Based on this analysis, the viability of maintaining certain programs is under review.

In line with NRC’s focus on engaging talent, an NRC‑wide on‑line orientation program (Fast Track to Success) was developed in 2011‑12 and implemented in May 2012. The program creates a “one‑stop” information source that provides a consistent approach to bringing new employees and visitors on board across the organization, eliminating the need for each portfolio or branch to set their own basic orientation program. The program integrates a component on understanding and living NRC values and also streamlines some of the administrative processes for new employees.

In 2011‑12, NRC continued to focus on the development of leadership capability across the organization. The third cycle of NRC’s Leadership Enrichment and Development (LEAD) training program was launched and 14 participants were selected. Participants completed multisource assessments, set development goals, participated in competency development workshops that focused on leading and building teams, fierce conversations, giving and receiving feedback; all of this was applied to project work on a real time NRC issue.

In addition to the LEAD intake, “Management 101”, NRC’s online learning resource for core management knowledge about key practices and policies, was updated to reflect new organization business practices such as program/project management, financial management, and vision/mission/values. Senior executive decided to make completion of all online modules with Management 101 mandatory for all managers and supervisors.

To support NRC in putting its new structure in place, between February and March 2012, HRB created a centralized core team dedicated to NRC transformation work, including business and strategic planning, organization design and employee mapping. The establishment of this team allowed HRB to support the critical activities of transformation in a coordinated and effective manner, while continuing to respond to daily operational issues. NRC also created a transition team to lead and manage change throughout the organization.

Training all managers and supervisors at a time of organizational uncertainty provided insight into the challenges faced in work planning and managing employee performance; data was shared with the senior executive to inform them of how changes were being received. Additionally, consultation on the new hiring policy and procedures afforded an opportunity to understand the challenges managers would face in the new operating environment. Those perspectives helped to shape the policy and procedures to better support talent acquisition for the new organization.

International recruitment programs were implemented to support specific organization goals that NRC had at the time; with the new direction of the organization, critically questioning the level of effort and projected return to the organization either in improving international business relationships or opening a door to attract needed talent becomes key to determining whether these programs continue or not.

Recognition by the Government of Canada for NRC’s credible expertise and policy advice on S&T innovation

As part of its vision for transformation, NRC has placed priority on recognition of its expertise relative to S&T innovation, by the Government of Canada itself. Efforts are being made to track and measure achievement of this new goal in 2012‑13 and future years. Already in 2011‑12, several successes reflect progress towards achievement of this NRC Goal:

NRC is recognized at senior government levels by the Government of Canada for its support of basic research and development of commercial innovations, as well as credible expertise and policy advice on S&T innovation. The Vice‑President of Engineering, Ian Potter, served twice as a witness to Parliamentary/Senate committees due to his expertise in transportation and energy.

Canada‑China S&T Agreement

NRC’s senior level involvement in international engagement also included its Life Sciences Vice President’s continued role as Biohealth Sector Coordinator under the Canada‑China S&T Agreement. The NRC VP’s relationship‑building with senior officials in China has opened doors within the sector and in other key areas for both researchers and companies. In China, the VP furthered a China‑Canada workshop on vaccines technologies and manufacturing, which was organized in the context of the Canada‑China S&T Agreement and aligned with Canadian government policy. The workshop had the goal of strengthening Canada’s global position as a world leader in vaccines and to foster dialogue between key Canadian and Chinese government officials, private sector stakeholders and researchers in the field of vaccine VP. As Sector Coordinator for Canada under the Canada‑China S&T Agreement, the VP introduced to Chinese counterparts the idea of aligning cooperation on vaccines technology development with the Joint Statement made by the Prime Ministers of Canada and China in 2009. This alignment helped joint committee members in facilitating their decision to approve the area of cooperation on vaccines at the Canada‑China Joint Committee meeting held in Vancouver in October 2011. The value of this decision was $1.5M each from CIHR, ISTP and industry, leveraged by the same amount from China.

R‑D Expert Panel Review

It is clear from the report “Innovation Canada: A Call to Action” that NRCIRAP is well‑regarded and widely viewed as effective and successful. It is one of the most well‑known programs available to businesses, second only to the Scientific Research and Experimental Development (SR&ED) program. The panel’s consultations revealed that NRCIRAP is widely regarded as an effective, well managed program that facilitates VP and commercialization activity by SMEs. This finding is corroborated by evidence collected through the Council of Canadian Academies’ 2006 assessment of Canada’s strengths and weaknesses in science and technology. A survey conducted as part of that assessment found that NRCIRAP was considered to be the federal government’s strongest program of direct support for the commercialization or translation of research into applications that benefit the economy or society. The panel recommended that NRCIRAP\xE2\x80\x99s budget be increased to enable it to build on its proven track record of facilitating innovation by SMEs throughout Canada.

DTAPP

On November 14, 2011, the Honourable Christian Paradis, Minister of Industry, announced an $80M investment over three years to help accelerate the adoption of information and communications technologies by small and medium-sized businesses. Given its national presence, NRCIRAP was selected by the Government of Canada to deliver this initiative to further provide small and medium-sized enterprises with its services and extensive network of technical experts. Additional information can be found in the in the Supplementary Information Tables accompanying NRC’s 2011‑12 Departmental Performance Report.

2012 Federal Budget

The Government made a strong commitment to the innovative firms that NRCIRAP serves by further investing $110M in NRCIRAP’s base funding to build on the strong economic impact achieved by the program. In addition, NRCIRAP is expected to use its experience and expertise to design and implement the new “concierge service” that was referenced in the Budget. Additional impacts on the Program and its clients are related to NRCIRAP being a major contributor to the delivery of both the Youth Employment Strategy and the Canadian Innovation Commercialization Program (CICP).

CICP

NRCIRAP has partnered with PWGSC since the inception of the Canadian Innovation Commercialization Program (CICP) to ensure successful delivery of this program. Managed through the Central Office, NRCIRAP has been working closely with PWGSC at various stages to develop the bid questionnaire for firms and the evaluation delivery process, ensure the IT tools are functional, develop and deliver training to NRCIRAP ITAs, make continual improvements from each round (three), as well as coordinate the bid evaluations. Over 100 ITAs were directly engaged in both rounds of bid evaluations, and we also anticipate this for the upcoming round. In round 1, 360 submissions were fully reviewed. In round 2, 336 submissions were initially screened, and 169 submissions moved on to a full review. Of the successful 37 pre-qualified submissions in round 2, 30 are NRCIRAP clients.

Aerospace Strategy

An NRCIRAP Director of the Quebec region was appointed to be part of two of the six working groups on the review of Canada’s Aerospace Strategy. More specifically, he is part of the “Technology Development, Demonstration and Commercialization” and the “Small Business and Supply Chain Development” working groups. The working groups are composed primarily of industry members with some government representatives supporting the discussions. The arms-length Aerospace Review has been mandated by the Government of Canada and is led by David Emerson, who is supported by a three-person Advisory Council and a Secretariat. Their first draft is planned for mid-summer, 2012.

Footnotes

Footnote 1

Astronomy in Canada. Hickling Arthurs Low (HAL) Corporation, 2011. Report available upon request.

Return to footnote 1 referrer