Human health therapeutics
NRC's Human Health Therapeutics (HHT) portfolio works hand in hand with industry to help biotech firms achieve success and save costs. As an R&D partner of choice, NRC‑HHT de‑risks critical steps in the development of biologics, vaccines, and delivery of large molecules to the brain, to help improve the health of Canadians. We add value to collaborators' products and accelerate their progress to market by overcoming challenges in preclinical and early clinical development, expanding product characterization, optimizing bioprocesses and their scale-up, and developing biomarkers.
Long description of the Therapeutic development pathway (value chain)
Therapeutic development pathway (value chain) covering the following steps:
- Basic research
- Target selection and validation
- Candidate design and optimization
- Preclinical development
- Investigational New Drug (IND) Application
- Clinical Phases 1+2
- Proof of Concept
- Clinical Phase 3
- New Drug Application
Human Health Therapeutics Portfolio active in steps 1-3. HHT core expertise in these steps shown inside a circle: Biomanufacturing, Biophysical and Functional Characterization. HHT also supports IND data packages and biomarkers for Phase 1. Products being co-developed in the HHT Portfolio's three programs (Biologics, Vaccines, and Therapeutics Beyond Brain Barriers) feed into the beginning of the value chain (before step 1) to show progression of products through each step towards market.
- Biologics and Biomanufacturing
Developing biotherapeutics against cancer, infectious, inflammatory and auto-immune diseases.
- Therapeutics Beyond Brain Barriers
Enabling large molecules to cross the blood brain barrier to treat diseases of the central nervous system.
- Vaccines and Immunotherapeutics
Developing prophylactic and therapeutic vaccines against cancer and emerging infections.
The NRC advantage
A globally recognized leader in the field of biologics and vaccine development, we offer our collaborators access to a highly qualified research team that can deliver first rate results while maintaining confidentiality. Through R&D services, collaborations, and licences, our clients can access "à la carte" expertise or collaborate with us for co‑development opportunities. We also transfer large molecule assets, bioprocessing solutions and other enabling technologies to our industrial clients to reinforce a strong, prosperous Canadian biomanufacturing sector with global impact.
- Peptides against cancer
- New cancer targets and matching antibodies
- Single-domain antibody for imaging of atherosclerotic plaques
- Peptides for imaging of tissue fibrosis
Biomarkers and molecule optimization
- ADAPT for antibody affinity maturation
- Biomarker sets for breast cancer drug response
- Multiplexed mutation testing for cancer drug response
Biologics delivery across the blood-brain barrier
- Synthetic archaeosome adjuvants for improved vaccine formulation
- AMVAD adjuvant for mucosal vaccines
- Salmonella vaccine vector
- Adenoviral vectors for vaccines and cancer therapy
- Immunomodulator for asthma treatment
Expression systems and biomanufacturing
Working with us
When you work with NRC‑HHT, you have many advantages at your fingertips:
- The largest biologics‑dedicated R&D team in Canada
- Expert involvement from target selection to cGMP‑like bioprocesses
- An experienced team with a track record of satisfied biopharma industry clients
- High‑caliber packages of technologies ready to licence
- Integrated resources throughout the NRC offering access to a wide range of capabilities
While we work with firms of all sizes, these resources make us an especially attractive partner for small- and medium‑sized enterprises, who frequently adopt a virtual wet laboratory model and have limited capacity to invest in research and development.
General Manager (acting)
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