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William Neil
Phone: 613-993-2555
Email: William.Neil@nrc-cnrc.gc.ca
Li-Lin Tay
Phone: 613-993-3919
Fax: 613-952-6337
Email: Li-Lin.Tay@nrc-cnrc.gc.ca
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Infrared Chemical Imaging of Biological Samples
In this new activity we are developing new metrological methods for the hyperspectral imaging in the infrared range of biological samples. Imaging is performed at the diffraction limit with infrared microscopy techniques on chemically non uniform sample slices whereby an infrared spectral signature acquired at each point in the sample plane. Changes in chemical content across a sample can thus be evaluated by comparing the infrared spectrum from point to point. The enabling technology for this method is that of the infrared focal plane array camera which has been recently combined with FTIR spectroscopy to provide rapid and precise infrared hyperspectral imaging. However for the method to be applied successfully, for example to histopathology, there are a number of measurement issues to be addressed including reference materials for spatial resolution, spectral resolution and signal to noise ratio. For example it is well known that clinical classification accuracy depends on the signal to noise ratio and accuracy of recorded data. Expertise will be applied in infrared chemical imaging by partnering with elements of the Canadian research community to address, in an interdisciplinary fashion, critical issues including measurement assurance, reliability and traceability.
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