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Jonathan Sharp
Phone: 403-221-3129
Fax: 403-221-3230
Email: Jonathan.Sharp@nrc-cnrc.gc.ca

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PEST 3D Imaging

Introducing slice gaps into 3DFT sequences for reduced acquisition time

NRC-IBD researchers, using a high-field 11.7 Tesla MRI system, have developed a three-dimensional imaging method that will reduce MR image acquisition time by 50 - 75 percent. The new method, called PEST-3DFT, is a faster 3D method that combines the benefits of the well-known 3D-phase encoding and multi-slice methods.

3DFT encoding is limited by the fact that the acquisitions can be too slow; 2D methods are limited because the number of slices available is sometimes insufficient for the requirement.

To address this problem, a new spatial-encoding method, based on the periodic spatial pre-saturation of the volume of interest with 3DFT MRI, was developed. See Figure 1.


Figure 1

a new spatial-encoding method

Schematic Pulse Sequence for 'PEST-3DFT'.


The PEST-3DFT sequence was implemented on a 500 MHz microscopy Bruker imaging system equipped with Magnex magnet and gradients.

Figure 2 shows two sets of results for a gradient-echo 3DFT sequence. The images in the left hand column are from small capillaries phantoms (1mm diameter). The images in the right hand column are from an ex vivo mouse head. In both cases the PEST 3DFT slices show a very similar appearance to the conventional 3DFT, while the wider slice shows significant blurring of details. The new technique will allow experiments to be conducted more quickly, with a large number of slices.


Figure 2

results for a gradient-echo 3DFT sequence

Images from small capillaries phantom and an ex-vivo mouse head using a 'PEST-3DFT', 3DFT with 64 and 128 phase encoding steps. All sequences were used as a gradient echo version.


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