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Biochips for Understanding and Diagnosis of Human Disease

The potential of new human pathogen detection technologies is far reaching. Using a variety of technologies established in NRC-GHI Phase 3 this program aims to develop new tools for understanding the molecular processes underlying critical pathogenic and genetic diseases. The end goal is to create rapid point-of-care diagnostic devices with the capacity to improve both the speed and accuracy of patient treatment. In particular, research will focus on diagnosing infectious agents responsible for hospital-acquired infections and threats to food and water safety - leading issues that affect both the national health-care system and the well-being and health of Canadians.

Research Success

Developing integrated devices that provide rapid point-of-care diagnosis of pathogens based on their genomic signature, is the goal of the NRC-GHI Biochips project. Central to the success of this technology are small on-chip assays – devices that can quantify, analyze and detect the chemical or molecular compounds found in various pathogens with high sensitivity and specificity. These small and efficient devices would assist in providing a sound “on-the-spot” clinical diagnosis and aide in determining the appropriate treatment, thereby preventing the spread of a variety of human disease.

Most recently, the NRC-GHI Biochips team moved closer towards their goal by developing conditions for the measurement of very small quantities of pathogen DNA. This advance brings the detection sensitivity of the device within the useful clinical range of measuring and identifying the existence of pathogens and represents a breakthrough in the real-time detection of biological samples.


Back to NRC-GHI Phase IV

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