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Title: |
Production of recombinant interferon proteins |
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NRC no.: |
11993 |
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Sector(s): |
Bioprocess |
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Inventors: |
Cass, Brian; Durocher, Yves; Loignon, Martin. |
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Status: |
United States, Application number 60/996,901, Filed 2007-12-10 |
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LOD |
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Abstract: |
A method of purifying a recombinant interferon protein involves providing an aqueous mixture of the recombinant protein and contaminating proteins; precipitating the contaminating proteins from the aqueous mixture at a pH in a range of from 0.5 to 6; separating the aqueous mixture from the precipitated contaminating proteins; and, eluting the separated aqueous mixture through a cation exchange column using a mobile phase with a salt or pH gradient, the gradient being from lower salt concentration or pH to higher salt concentration or pH, to produce a recombinant interferon protein fraction separated from other components of the aqueous mixture. The method provides for the recovery of recombinant interferon proteins in better yield and purity. |
For more information, please contact:
Christine St-Jean
Intellectual Property Coordinator, Industrial Affairs
E-mail: christine.st-jean@cnrc-nrc.gc.ca
Note: Data on abstracts is shown in the official language in which it was submitted.
