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- NRC Biotechnology Research Institute
- NRC Canadian Neutron Beam Centre
- NRC Canadian Photonics Fabrication Centre
- NRC Genomics and Health Initiative
- NRC Imaging Network Portal
- NRC Institute for Biodiagnostics
- NRC Institute for Biological Sciences
- NRC Institute for Marine Biosciences
- NRC Institute for Microstructural Sciences
- NRC Institute for Nutrisciences and Health
- NRC Plant Biotechnology Institute
- National Institute for Nanotechnology
- National Research Council Canada
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Enquiries: NRC-GHI
Fax: 613-947-3067
Email: ghi.info@nrc.gc.ca
100 Sussex Drive
Ottawa,
Ontario,
K1A 0R6
Canada
Infrastructure
- Biotechnology Research Institute
- Industrial Materials Institute
- Institute for Biodiagnostics
- Institute for Biological Sciences
- Institute for Information Technology
- Institute for Marine Biosciences
- National Institute for Nanotechnology
- Institute for Microstructural Sciences
- Plant Biotechnology Institute
- Steacie Institute for Molecular Sciences
GHI Infrastructure Platforms
GHI makes use of two core infrastructure facilities in DNA Microarray and Proteomics to support its ongoing Phase 4 research programs. These facilities undertake research and client-oriented "service" activities utilizing state of the art technologies.
DNA Microarray Technology
DNA microarray, or DNA chips are fabricated by high-speed robotics, generally on glass but sometimes on nylon substrates, for which probes with known identity are used to determine complementary binding, thus allowing massively parallel gene expression and gene discovery studies. An experiment with a single DNA chip can provide researchers information on thousands of genes simultaneously – a dramatic increase in throughput over older methods of observing gene expression. Read about the NRC microarray facility located in Montreal at the Biotechnology Research Institute.
Proteomics
Proteomics is the analysis of complete complements of proteins. Proteomics includes not only the identification and quantification of proteins, but also the determination of their localization, modifications, interactions, activities, and, ultimately, their function. Initially encompassing just two- dimensional (2D) gel electrophoresis for protein separation and identification, proteomics now refers to any procedure that characterizes large sets of proteins. The explosive growth of this field is being driven by multiple factors, including newly developed mass spectrometry approaches and innovative computational tools and methods to process, analyze, and interpret very large amounts of data. Through the GHI, the NRC has developed a major proteomics technology platform located in Ottawa at the Institute for Biological Sciences.
